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Genotoxicity from exposure to cigarettes in young smokers in Colombia. Sierra-Torres II. La correspondencia debe dirigirse a Carlos H. Telefax: All of them were between 19 and 29 years old and none used psychoactive drugs, suffered from chronic or infectious diseases, or had been exposed to chemotherapy or radiation therapy or to chemical agents in their work. A survey was used to obtain demographic information, occupational information type of employment, type of and length of exposure to chemical agents , lifestyle information consumption of alcoholic beverages and psychoactive drugs , and information on smoking current or former smoker, number of cigarettes smoked daily, length of time smoking, and type of cigarettes smoked.
The microscopic study of the CAs using lymphocyte cultures was carried out under the light microscope with X magnification. The frequency of CAs was adjusted for alcohol consumption, using a univariate linear model.
These results should be taken into account in order to formulate national smoking prevention policies and to evaluate their outcomes, from both the social, economic, and environmental standpoint and the standpoint of the health of future generations. Se ha estimado que las muertes anuales asociadas con el consumo de cigarrillos en el mundo fueron de 3 millones en y de 4 millones en , y se espera que alcancen la cifra de 8,4 millones en Todos los reactivos utilizados fueron de alta pureza Sigma Chemical, St.
El consumo de cigarrillos es una de las principales causas de enfermedad y muerte en todo el mundo 1. World Health Organization. The world health report reducing risks, extending healthy life. Geneva: WHO; Building the evidence base for global tobacco control. Bull World Health Organ. Ramsay S. Smoking in Latin America: a major public health problem.
Cad Saude Publica. Baker RR. Product formation mechanisms inside a burning cigarette. Progr Energy Combustion Sci. International Agency for Research on Cancer. Monograph on the evaluation of the carcinogenic risk of chemicals to humans. Lyon: IARC; Hoffmann D, Hoffmann I. J Toxicol Environ Health. Lung cancer. Fagerstrom K. The epidemiology of smoking: health consequences and benefits of cessation. Factors contributing to chromosome damage in lymphocytes of cigarette smokers.
Mutat Res. Natarajan AT, Obe G. Screening of human populations for mutations induced by environmental pollutants: use of human lymphocyte system. Ecotoxicol Environ Saf. Factors contributing to discrepancies in population monitoring studies. Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens. Cancer Res. Evans HJ, Scott D. Influence of DNA synthesis on the production of chromatid aberrations by X rays and maleic hydrazide in Vicia faba.
Polymorphisms for chemical metabolizing genes and risk for cervical neoplasia. Environ Mol Mutagen. The Helsinki Declaration. Orv Hetil. Cytogenetic monitoring of farmers exposed to pesticides in Colombia. Environ Health Perspect. Simple differential Giemsa staining of sister chromatids after treatment with photosensitive dyes and exposure to light and the mechanism of staining.
Whorton EBJ. Some experimental design and analysis considerations for cytogenetics studies. Environ Mutagen. Colombia, Ministerio de Salud. Sorsa M. Experimental studies on the mutagenicity and related effects of low-tar and high-tar cigarettes in relation to smoker exposures. Predisposing genes and increased chromosome aberrations in lung cancer cigarette smokers. Combined genetic polymorphism and risk for development of lung cancer.
Effect of epoxide hydrolase polymorphisms on chromosome aberrations and risk for lung cancer. Cancer Genet Cytogenet. Observation of chromosome aberration and micronucleus formation in peripheral blood lymphocytes among cigarette smokers. Sierra-Torres MS. Cytogenetic assays for monitoring populations exposed to environmental mutagens. Occup Med. Br Med J. Manuscrito recibido el 4 de noviembre de Rev Panam Salud Publica.
2002, Número 2
Genotoxicity from exposure to cigarettes in young smokers in Colombia. Sierra-Torres II. La correspondencia debe dirigirse a Carlos H. Telefax: All of them were between 19 and 29 years old and none used psychoactive drugs, suffered from chronic or infectious diseases, or had been exposed to chemotherapy or radiation therapy or to chemical agents in their work.
Introduction: The 3q29 microdeletion and microduplication syndromes are characterised by a marked phenotypic heterogeneity, and delayed development and a mild-moderate degree of intellectual disability are the most frequent clinical manifestations. Case reports: Two patients with reciprocal chromosomal aberrations in the 3q29 region. The patient with 3q29 microdeletion presented learning disabilities, borderline microcephaly, mild facial dysmorphism, attentional deficit and impulsiveness, and anxious and obsessive traits. The patient with reciprocal 3q29 microduplication presented learning disabilities, mild facial dysmorphism and a disruptive behavioural profile that was not previously associated with this duplication.