ANTIBIOTICOS BETALACTAMICOS EN ODONTOLOGIA PDF

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Antibiotics: therapeutic importance and perspectives for the discovery and development of new agents. There is a continuous need for antibiotics, mainly with new mechanisms of action, since infectious diseases represent the second major cause of death in the world and bacteria resistance levels are high. This review describes the contribution of microbial natural products for the development of the major antibiotic classes, the mechanisms of action of current antibiotics, some modern approaches involving genetic tools for the discovery and development of new antibiotics from microbial products and antibiotics in clinical trials.

Keywords: microbial natural products; drug discovery; antibiotics. Figura 1. Figura 2. A estreptomicina 9 , principal representante da classe, foi isolada em de Streptomyces griseus , um micro-organismo de solo. O cloranfenicol 11 foi isolado a primeira vez do micro-organismo Streptomyces venezuela.

A lincomicina foi isolada do micro-organismo de solo Streptomyces lincolnensis. A rifamicina B 16 foi isolada de Streptomyces mediterranei , reclassificado como Nocardia mediterranei. Sulfonamidas e trimetoprim. Quinolonas e fluoroquinolonas. Novas fontes de produtos naturais. O guanacastepeno A 50 apresentou atividade frente a cepas resistentes de Staphylococcus aureus e Enterococcus faecalis e o guanacastepeno I 51 apresentou atividade antimicrobiana frente a S.

O actinomiceto Streptomyces sp. Novos ensaios antibacterianos. Walsh, C. Patrick, G. Nicolaou, K. Projan, S. Fernandes, P. Pupo, M. Abraham, D. Durante-Mangoni, E. Wright, G. Em ref. Mukhtar, T. Pace, J. L: Yang, G.

Allington, D. Drlica, K. Agents Ch. Bozdogan, B. Levy, S. Abeylath, S. Drug Deliv. Hiramatsu, K. Drug Delivery Rev. Lambert, P. Kumar, A. Happi, C. Moellering, R. Payne, D. Drug Discovery , 6 , Luzhetskyy, A. Coates, A. Clardy, J. Mincer, T. Bister, B. Kwon, H.

Wang, J. Pearson, H. Nett, M. Gunatilaka, A. Gallo, M. Em Microbial Biotechnology; Saikai, R. Castillo, U. Brady, S. Gibbons, S. Gebhardt, K. Thouzeau, C. Mackintosch, J. Mygind, P. Brandi, L. Ondeyka, J. Handelsman, J. Gillespie, D. Banik, J.

Hopwood, D. Baltz, R. Heide, L. McAlpine, J. Bergmann, S. Lautru, S. Mills, S. Rachakonda, S. Butler, M. Freiberg, C. Proteomics , 5 , Gaweska, H. Baker, D. Fernandes, T.

Chen, H. Yusupov, M. Blount, K. Mukhopadhyay, A. Kulanthaivel, P. Mariani, R. Banskota, A. Fulco, P. Yamashita, A. Watters, A. He, H. Naidu, B. Rittenhouse, S. Agents Chemother.

Johnson, A. Livermore, D. Secretaria Executiva Av.

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Interacciones farmacológicas relacionadas con la administración de antibióticos betalactámicos.

Antibiotics: therapeutic importance and perspectives for the discovery and development of new agents. There is a continuous need for antibiotics, mainly with new mechanisms of action, since infectious diseases represent the second major cause of death in the world and bacteria resistance levels are high. This review describes the contribution of microbial natural products for the development of the major antibiotic classes, the mechanisms of action of current antibiotics, some modern approaches involving genetic tools for the discovery and development of new antibiotics from microbial products and antibiotics in clinical trials. Keywords: microbial natural products; drug discovery; antibiotics. Figura 1.

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Sin embargo, hasta la fecha son pocos los estudios realizados para determinar su incidencia. Universidad de Murcia 4 Profesor Titular del Dpto. Universidad de Barcelona 6 Profesor Titular del Dpto. Universidad de Sevilla 8 Asociada. Universidad de Granada 10 Profesor Asociado. Universidad de Salamanca 11 Profesor del Dpto. Facultad de Ciencias de la Salud.

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